Short tandem repeats (STR) in cattle genomics and breeding

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Systematic Profiling of Short Tandem Repeats in the Cattle Genome

Short tandem repeats (STRs), or microsatellites, are genetic variants with repetitive 2–6 base pair motifs in many mammalian genomes. Using high-throughput sequencing and experimental validations, we systematically profiled STRs in five Holsteins. We identified a total of 60,106 microsatellites and generated the first high-resolution STR map, representing a substantial pool of polymorphism in d...

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Short tandem repeats and genetic variation.

Single nucleotide polymorphisms (SNPs) are widely distributed in the human genome and although most SNPs are the result of independent point-mutations, there are exceptions. When studying distances between SNPs, a periodic pattern in the distance between pairs of identical SNPs has been found to be heavily correlated with periodicity in short tandem repeats (STRs). STRs are short DNA segments, ...

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How is genomics changing cattle breeding ?

Abstract Text: Genomic selection offers considerable flexibility to increase genetic trends in dairy cattle breeding, through a decrease in generation interval, an increase in selection intensity, and an increase in reliability for females and for low heritability traits. It is also an opportunity for more sustainable breeding, in terms of breeding goal and genetic variability. With a shorter g...

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Rapid detection of expanded short tandem repeats in personal genomics using hybrid sequencing

MOTIVATION Long expansions of short tandem repeats (STRs), i.e. DNA repeats of 2-6 nt, are associated with some genetic diseases. Cost-efficient high-throughput sequencing can quickly produce billions of short reads that would be useful for uncovering disease-associated STRs. However, enumerating STRs in short reads remains largely unexplored because of the difficulty in elucidating STRs much l...

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[Detection of short tandem repeat (STR) polymorphisms by microchip electrophoresis for individual identification of cattle].

A simple and rapid detection of short tandem repeat (STR) markers was studied as a screening test for individual identification of cattle. DNAs were extracted from eight commercial beef samples by a proteinase K-boil method followed by purification with 2-propanol precipitation. Five STR markers, known to be highly polymorphic, were amplified by PCR and analyzed both by a conventional sequencin...

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ژورنال

عنوان ژورنال: Biotechnology in Animal Husbandry

سال: 2018

ISSN: 1450-9156,2217-7140

DOI: 10.2298/bah1802127t